Transcription-driven establishment of DNA methylation at the PWS/AS imprinted region
Josephine Haake, Alexander Lederhof, Claudia Pommerenke, Laura Steenpaß
This study shows that transcription across the PWS-SRO is necessary but not sufficient for de novo DNA methylation at the PWS/AS locus, requiring differentiation-dependent cues.
bioRxiv · Sep 14, 2026 · PreprintGenetics