A model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction
Steven Watterson, Maria-Luisa Guerriero, Mathieu Blanc, Alexander Mazein, Laurence Loewe, Kevin Robertson, Holly Gibbs, Guanghou Shui, Markus Wenk, Jane Hillston, Peter Ghazal
The paper models cholesterol biosynthesis pathway regulation, showing immune responses cause gradual flux reduction while statin-like treatments cause abrupt flux reduction, with immune regulation being more specific.
Biochimie · Mar 1, 2013Peer-reviewedSystems Biology