Intramolecular interactions enhance the potency of gallinamide A analogs against Trypanosoma cruzi
Elany Barbosa da Silva, Vandna Sharma, Lilian Hernández Alvarez, Arthur H. Tang, Alexander Stoye, Anthony John O’Donoghue, William H. Gerwick, Richard J. Payne, James Hobson McKerrow, Larissa M. Podust
The paper evaluates gallinamide A and its analogs against Trypanosoma cruzi, finding that intramolecular π-π stacking interactions enhance potency by improving solubility and permeability.
bioRxiv · Dec 22, 2021 · PreprintMolecular Biology