Elany Barbosa da Silva

This study identifies semicarbazone and thiosemicarbazone analogs as competitive inhibitors of SARS-CoV-2 Mpro through virtual screening and biochemical validation.

This study identifies aspartic proteases as active enzymes in acidified wound fluid, showing their activity is optimal between pH 3.0 and 3.8 and persists for ten days post-injury.

This paper develops a recombinant Pf20S platform for structural analysis and inhibitor design, identifying a selective inhibitor with high potency against Plasmodium falciparum proteasome.

The paper evaluates thio- and seleno-semicarbazones and their azole derivatives for treating African trypanosomiasis, finding Se derivatives more active than S analogues and highlighting the importance of combining TbrCATL inhibition with antioxidant activity.

This study identifies three new ketomemicin analogs from Salinispora pacifica, maps their biosynthetic gene cluster across Salinispora species, and reports their protease inhibitory activity.

The paper develops subunit-specific proteasome substrates for Schistosoma species, showing improved performance and cross-species applicability.

The paper evaluates gallinamide A and its analogs against Trypanosoma cruzi, finding that intramolecular π-π stacking interactions enhance potency by improving solubility and permeability.