Model based normalization improves differential expression calling in low-depth RNA-seq
Pavel N. Zakharov, Alexey A. Sergushichev, Alexander V. Predeus, Maxim N. Artyomov
The paper introduces a normalization method that improves differential expression analysis at low sequencing depths by re-normalizing samples using a Pareto-like distribution model.
bioRxiv · Jan 15, 2015 · PreprintGenomics