Single-cell neural network classifiers reveal that PM21 NK cell expansion is dependent on B cell signaling
Michael Tsabar, Shaoline Sheppard, Sarah Sturtevant, Yinyin Huang, Ryan M. J. Genga, Margaret E. Magaletta, Matthew P. Kodrasov, Elizabeth Tran, Kyle Smith, Juhyung Jung, Matthew Sullivan, Andre Kurlovs, Virginia Savova, Diana Stoycheva, Bruno Figueroa, , Giorgio Gaglia
The paper uses single-cell transcriptomics and neural network classifiers to identify B cell signaling as critical for NK cell expansion in allogenic therapy.
bioRxiv · Sep 23, 2025 · PreprintSystems Biology