Michael Tsabar

The paper uses single-cell transcriptomics and neural network classifiers to identify B cell signaling as critical for NK cell expansion in allogenic therapy.

This study develops an AAV vector for ARSA gene replacement in MLD, showing improved brain biodistribution and therapeutic effects in mice and non-human primates.

The paper investigates how p21 transcription variability arises through an incoherent feedforward loop involving p53 and MDM2, showing it enables rapid p21 induction and treatment-tolerant cell states.

The paper identifies universal and cell type specific p53 DNA binding sites by analyzing 12 epithelial cell lines after ionizing radiation.

The paper uses fluorescent markers to study DSB formation and repair dynamics in yeast, finding that DSB foci coalesce and dissociate without requiring Rad2 protein.