Yinyin Huang

Single-cell neural network classifiers reveal that PM21 NK cell expansion is dependent on B cell signaling

The paper uses single-cell transcriptomics and neural network classifiers to identify B cell signaling as critical for NK cell expansion in allogenic therapy.

High-Throughput Screening for Myelination Promoting Compounds Using Human Stem Cell-derived Oligodendrocyte Progenitor Cells Identifies Novel Targets

The paper identifies novel pathways that enhance oligodendrocyte maturation and myelination through high-throughput screening of 2500 compounds using engineered human stem cell-derived OPCs.

Disrupted microglial iron homeostasis in progressive multiple sclerosis

This study identifies SPMS-enriched microglia subsets with disrupted iron homeostasis and oxidative stress using snRNA-seq and validates findings with histology and RNA-scope.

Single Nuclei Sequencing of Human Putamen Oligodendrocytes Reveals Altered Heterogeneity and Disease-Associated Changes in Parkinson's Disease and Multiple System Atrophy

The paper profiles single nuclei from human putamen in Parkinson's Disease and Multiple System Atrophy, revealing disease-specific oligodendrocyte heterogeneity and gene expression changes.

Single Cell Atlas of Human Putamen Reveals Disease Specific Changes in Synucleinopathies: Parkinson's Disease and Multiple System Atrophy

The paper constructs a single-cell atlas of human putamen tissue from healthy controls, Parkinson's Disease, and Multiple System Atrophy to identify cell-type specific disease changes.