AAV-DJ is Superior to AAV9 for Targeting Brain and Spinal Cord, and De-Targeting Liver Across Multiple Delivery Routes in Mice
Monika Chauhan, Audrey L. Daugherty, Fatemeh Khadir, Ozgun Firat Duzenli, Alexandra Hoffman, Jennifer A Tinklenberg, Peter B. Kang, George Aslanidi, Christina A. Pacak
This study compares AAV-DJ and AAV9 for CNS targeting and off-target effects in mice across different delivery routes, finding AAV-DJ superior for CNS and reduced liver/kidney transduction.
Journal of Translational Medicine · Sep 5, 2024Peer-reviewedMolecular Biology