Protein Level Variability Determines Phenotypic Heterogeneity in Proteotoxic Stress Response
Marie Guilbert, François Anquez, Alexandra Pruvost, Quentin Thommen, Emmanuel Courtade
The paper identifies protein-level variability as the source of phenotypic heterogeneity in the heat shock response network, showing how chaperone expression and network ultrasensitivity contribute to diverse cellular responses.
FEBS Journal · Mar 28, 2020Peer-reviewedSystems Biology