François Anquez

The paper uses live single-cell imaging to show cancer stem cells form spatial niches and undergo reprogramming influenced by both lineage and cell-cell interactions.

The paper uses metabolomics and fluxomics data to model the pentose phosphate pathway's response to oxidative stress, revealing cooperative regulatory mechanisms involving G6PD, PGI, and GAPD.

The paper identifies protein-level variability as the source of phenotypic heterogeneity in the heat shock response network, showing how chaperone expression and network ultrasensitivity contribute to diverse cellular responses.

The paper uses single-cell FRET measurements in E. coli to show signaling variability across and within cells, attributing it to stochastic enzyme activities and receptor-kinase dynamics.