Author

Alexey V. Orlov

Prokhorov General Physics Institute

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Bioinformatics· 1

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Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:matrix factorization· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

German A. AshnieviD· 1 shared Natalia N. Orlova· 1 shared Petr Ivanovich NikitiniD· 1 shared Yulia V. Makus· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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1 shared paperBioinformatics

German A. AshnievORCID

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1 paper

Recent·Most cited

What Do Biological Foundation Models Compute? Sparse Autoencoders from Feature Recovery to Mechanistic Interpretability

Alexey V. Orlov, Yulia V. Makus, German A. Ashniev, Natalia N. Orlova, Petr Ivanovich Nikitin

This paper reviews sparse autoencoders applied to biological foundation models, finding they recover interpretable biological features but lack experimental validation of mechanistic understanding.

bioRxiv · Mar 6, 2026 · PreprintBioinformatics