Author

Natalia N. Orlova

Prokhorov General Physics Institute

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Bioinformatics· 1

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Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:matrix factorization· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

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Alexey V. Orlov· 1 shared German A. AshnieviD· 1 shared Petr Ivanovich NikitiniD· 1 shared Yulia V. Makus· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperBioinformatics

Alexey V. Orlov

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1 paper

Recent·Most cited

BioinformaticsbioRxivPreprintMar 6, 2026

What Do Biological Foundation Models Compute? Sparse Autoencoders from Feature Recovery to Mechanistic Interpretability

Alexey V. Orlov, Yulia V. Makus, German A. Ashniev…·Petr Ivanovich Nikitin

This paper reviews sparse autoencoders applied to biological foundation models, finding they recover interpretable biological features but lack experimental validation of mechanistic understanding.

DOI 10.64898/2026.03.04.709491

protein sequenceDNA methylation

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