Context-dependent determinants of CRISPR-Cas9 editing efficiency revealed through cross-species endogenous editing analysis
Shai Cohen, Shaked Bergman, Adi Yahalom, Alina Wiener, Anat Lavi-Itzkovitz, Anat Maoz, Anna Rice, Dan Dominissini, Dana Furest, David Simanovich Zini, Dongqi Li, Dov Gertz, Ehud Landau, Ester Yeshayahou, Eyal Emmanuel, , Tamir Tuller
The paper identifies context-dependent factors affecting CRISPR-Cas9 editing efficiency across species using endogenous editing data and shows that repair outcomes are conserved.
bioRxiv · Mar 18, 2026 · PreprintSynthetic Biology