Stereociliary localization and function of the tip-link protein PCDH15-CD2 are regulated by the PDZ-scaffold NHERF-1
Aray Adylkhan, Anna Y. Andreeva, Xufeng Qiu, Zariat Shatkenova, Phillip Wilson, Alison Lim, Daniel Son, Raymond Huang, Ulrich W. Mueller, Xiaowei Lu
This study identifies NHERF-1 as a regulator of CD2 localization and function in auditory hair cells, showing its role in maintaining hearing and preventing degeneration.
bioRxiv · Oct 29, 2026 · PreprintCell Biology