TIAM1 signaling drives prostatic budding and branching phenotypes and is a potential therapeutic target for BPH
Hamed Khedmatgozar, Sayanika Dutta, Michael Dominguez, Daniel Latour, Melanie Johnson, Mohamed Fokar, Irfan Warraich, Werner de Riese, Allan Haynes, Robert J. Matusik, Luis Brandi, Srinivas Nandana, Manisha Tripathi
This study identifies TIAM1-RAC1 signaling as a driver of prostatic budding and branching in BPH and suggests it as a therapeutic target.
bioRxiv · Feb 2, 2024 · PreprintCell Biology