Compound biological signatures facilitate phenotypic screening and target elucidation
Alvaro Cortes Cabrera, Daniel Lucena-Agell, Mariano Redondo-Horcajo, Isabel Barasoain, Fernando Diaz, Bernhard Fasching, Paula Petrone
The paper introduces BIOSEA, a method to identify compounds that reproduce desired cellular phenotypes using historical bioactivity data, finding novel inhibitors and drug repurposing opportunities.
bioRxiv · Mar 2, 2016Pharmacology & Toxicology