Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration
Alicia R. Lane, Noah E. Scher, Shatabdi Bhattacharjee, Stephanie A. Zlatic, Anne M. Roberts, Avanti Gokhale, Kaela S. Singleton, Duc Minh Duong, Mike McKenna, William L. Liu, Alina Baiju, Felix G Rivera Moctezuma, Tommy Tran, Atit A. Patel, Lauren B. Clayton, , Victor Faúndez
The paper investigates how neuronal cells adapt to copper deficiency by increasing protein synthesis through mTORC1 activation and reduced PERK signaling in multiple model systems.
Molecular Biology of the Cell · Jan 29, 2025Peer-reviewedNeuroscience