Distinct signaling mechanisms and proteome phenotypes are elicited by compartment-specific genetic defects of copper homeostasis
Alicia R. Lane, Nadia Gonzalez, Avanti Gokhale, Stephanie A. Zlatic, Brooke M. Allen, Noah E. Scher, Anne M. Roberts, Duc Minh Duong, Blaine R. Roberts, Alysia D. Vrailas‐Mortimer, Erica Werner, Victor Faúndez
The paper compares the effects of copper deficiency in CTR1- and COX17-deficient cells using multiomics approaches, revealing distinct signaling mechanisms and proteome responses.
Molecular Biology of the Cell · May 13, 2026Peer-reviewedCell Biology