Selective whole genome amplification as a tool to enrich specimens with low Treponema pallidum genomic DNA copies for whole genome sequencing
Charles M. Thurlow, Sandeep J. Joseph, Lilia Milkova Ganova-Raeva, Samantha S. Katz, Lara Pereira, Cheng Chen, Alyssa Debra, Kendra Vilfort, Kimberly Workowski, Stephanie E. Cohen, Hilary Reno, Yongcheng Sun, Mark Burroughs, Mili Sheth, Kai-Hua Chi, , Allan Pillay
This paper develops a selective whole genome amplification method to enrich low T. pallidum DNA samples for whole genome sequencing, achieving high coverage and identifying azithromycin resistance mutations.
mSphere · May 2, 2022Peer-reviewedGenomics