Smoking-dependent expression alterations in nasal epithelium reveal immune impairment linked to germline variation and lung cancer risk
Maria Stella de Biase, Florian Massip, Tzu‐Ting Wei, Federico Manuel Giorgi, Rory Stark, Amanda Stone, Amy Gladwell, MarJn O’Reilly, Daniel Schütte, Ines de Santiago, Kerstin B. Meyer, Florian M. Markowetz, Bruce A.J. Ponder, Robert Campbell Rintoul, Roland F. Schwarz
The paper identifies persistent smoking-related immune alterations in airway tissues and links them to genetic risk factors and lung cancer risk using transcriptomic data and GWAS integration.
medRxiv · Nov 24, 2021 · PreprintGenetic & Genomic Medicine