Author

Daniel Schütte

University of CologneORCID 0000-0002-4746-537XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Research Focus:database / resource· 2 Organism:human· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Approach:Bayesian inference· 1 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Roland F. SchwarziD· 3 shared Amanda Stone· 1 shared Amy Gladwell· 1 shared Bruce A.J. Ponder· 1 shared Federico Manuel GiorgiiD· 1 shared Florian M. MarkowetziD· 1 shared Florian MassipiD· 1 shared Ines de SantiagoiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBioinformatics

Roland F. SchwarzORCID

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Author profile →

3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintAug 9, 2026

pyfraglib: An integrated cfDNA fragmentomics platform

Daniel Schütte, Laura Godfrey, Jessica Schneider…·Roland F. Schwarz

pyfraglib provides a platform for cfDNA fragmentomics analysis, including fragment extraction, feature modeling, cohort comparison, and simulation, and identifies a high-risk subgroup in CNSL patients.

DOI 10.64898/2026.07.22.740152

humanwhole-genome sequencing

BioinformaticsbioRxivPreprintMar 16, 2026

SC-BIG: A Hierarchical Bayesian Model for Bulk-Informed Single Nucleotide Variant Calling in Single Cells

Daniel Schütte, Thomas J. Y. Kono, Roland F. Schwarz

SC-BIG improves single-cell SNV detection by integrating bulk sequencing data, outperforming existing methods in simulated scenarios.

DOI 10.64898/2026.03.12.705671

whole-genome sequencingBayesian inference

Genetic & Genomic MedicinemedRxivPreprintNov 24, 2021

Smoking-dependent expression alterations in nasal epithelium reveal immune impairment linked to germline variation and lung cancer risk

Maria Stella de Biase, Florian Massip, Tzu‐Ting Wei…·Roland F. Schwarz

The paper identifies persistent smoking-related immune alterations in airway tissues and links them to genetic risk factors and lung cancer risk using transcriptomic data and GWAS integration.

DOI 10.1101/2021.11.24.21266740

humanbulk RNA-seq