A molecular inversion probe and sequencing-based microsatellite instability assay for high throughput cancer diagnostics and Lynch syndrome screening
Richard Gallon, Christine Hayes, Lisa Redford, Ghanim Alhilal, Ottie O’Brien, Amanda Waltham, Stephanie Needham, Mark Arends, Anca Oniscu, Angel Miguel Alonso, Sira Moreno Laguna, Harsh Sheth, Mauro Santibanez-Koref, Michael S Jackson, John Burn
This paper develops a sequencing-based assay using molecular inversion probes to detect microsatellite instability and BRAF V600E mutations in colorectal cancer, enabling high-throughput diagnostics and Lynch syndrome screening.
bioRxiv · Aug 1, 2018 · PreprintCancer Biology