Persistence of tobacco-mutated alveolar progenitor cells after smoking cessation mirrors long term risk of lung adenocarcinoma
Moritz Jakob Przybilla, Amany Ammar, Hugh Selway‐Clarke, Andrew R. J. Lawson, Mike Spencer Chapman, Hyunchul Jung, Kate H.C. Gowers, Pantelis A. Nicola, Marie-Belle El Mdawar, Manuela Platé, Kate E J Otter, Zoe Hagel, Chuen Ryan Khaw, Inigo Martincorena, Adam Pennycuick, , Sam M. Janes
The paper shows that persistent mutation burdens in alveolar progenitor cells after smoking cessation explain the continued risk of lung adenocarcinoma compared to squamous cell carcinoma.
bioRxiv · Jul 9, 2026 · PreprintGenomics