Moritz Jakob Przybilla

The paper shows that persistent mutation burdens in alveolar progenitor cells after smoking cessation explain the continued risk of lung adenocarcinoma compared to squamous cell carcinoma.

The paper identifies molecular signatures of Crohn's disease using scRNA-seq data from terminal ileal biopsies, highlighting key cell types and pathways involved in disease pathogenesis.

This study develops human epithelioids as a 3D culture system that maintains architecture, heterogeneity, and clonal evolution over time, enabling long-term studies of tissue dynamics and therapeutic responses.

The paper identifies endogenous guanine adducts as drivers of tissue-specific mutagenesis and shows that Polκ and DNA repair mechanisms suppress these mutations.

The paper introduces a high-accuracy sequencing method to detect somatic mutations in tissues, revealing extensive selection and driver mutations in oral epithelium and blood samples.