A MUC5B polymorphism associated with Idiopathic Pulmonary Fibrosis mediates overexpression through decreased CpG methylation and C/EBPb transcriptional activation
Amaranta U. Armesto-Jimenez, Ari Jón Arason, Ólafur Andri Stefánsson, Gunnar Guðmundsson, Þórarinn Guðjónsson, Magnús K. Magnússon
This study identifies a MUC5B polymorphism associated with IPF that increases expression through reduced CpG methylation and enhanced C/EBPβ transcriptional activation.
bioRxiv · Dec 18, 2019 · PreprintGenetics