Monogenic and Polygenic Contributions to QTc Prolongation in the Population
Victor D. Nauffal, Valerie N. Morrill, Sean Joseph Jurgens, Seung Hoan Choi, Amelia W. Hall, Lu-Chen C Weng, Jennifer L. Halford, Christina Anne Austin-Tse, Christopher M. Haggerty, Stephanie L. Harris, Eugene Wong, Álvaro Alonso, Dan E. Arking, Emelia J. Benjamin, Eric Boerwinkle, , for the TOPMed Investigators
This study investigates how rare and common genetic variations contribute to QT interval duration, finding that both monogenic and polygenic factors influence QTc prolongation, with polygenic risk modulating the effect of rare variants.
Circulation · Apr 7, 2022Peer-reviewedGenetic & Genomic Medicine