Author

Brandon K. Fornwalt

Geisinger Health SystemORCID 0000-0002-6231-9442Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:GWAS summary statistics· 2 Research Focus:variant effect prediction· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Christopher M. HaggertyiD· 3 shared Adolfo CorreaiD· 2 shared Alanna C. MorrisoniD· 2 shared Braxton D. MitchelliD· 2 shared Bruce M. PsatyiD· 2 shared Charles L KooperbergiD· 2 shared Christina Anne Austin-TseiD· 2 shared Elsayed Z. SolimaniD· 2 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Christopher M. HaggertyORCID

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Author profile →

3 papers

Recent·Most cited

Endophenotype Effect Sizes Provide Evidence Supporting Variant Pathogenicity in Monogenic Disease Susceptibility Genes

Jennifer L. Halford, Valerie N. Morrill, Seung Hoan Choi, Sean Joseph Jurgens, Giorgio E. M. Melloni, Nicholas Marston, Lu-Chen C Weng, Victor D. Nauffal, Amelia Weber Hall, Sophia Gunn, Christina Anne Austin-Tse, James P. Pirruccello, Shaan S. Khurshid, Heidi L. Rehm, Emelia J. Benjamin, , Steven A. Lubitz

The paper shows that variant effect sizes on quantitative endophenotypes support pathogenicity in monogenic disease genes.

Nature Communications · Aug 30, 2022Peer-reviewedGenetic & Genomic Medicine

Loss-of-Function FLNC Variants are Associated with Arrhythmogenic Cardiomyopathy Phenotypes when Identified through Exome Sequencing of a General Clinical Population

Eric D. Carruth, Maria Qureshi, Amro Alsaid, Melissa Kelly, Hugh G Calkins, Brittney A. Murray, Crystal Tichnell, Amy Curry Sturm, Aris Baras, Henry Lester Kirchner, Brandon K. Fornwalt, Cynthia A. James, Christopher M. Haggerty

The paper identifies FLNC loss-of-function variants in a clinical population and finds they are associated with increased odds of arrhythmogenic cardiomyopathy phenotypes.

Circulation Genomic and Precision Medicine · Jun 14, 2022Peer-reviewedGenetic & Genomic Medicine

Monogenic and Polygenic Contributions to QTc Prolongation in the Population

Victor D. Nauffal, Valerie N. Morrill, Sean Joseph Jurgens, Seung Hoan Choi, Amelia W. Hall, Lu-Chen C Weng, Jennifer L. Halford, Christina Anne Austin-Tse, Christopher M. Haggerty, Stephanie L. Harris, Eugene Wong, Álvaro Alonso, Dan E. Arking, Emelia J. Benjamin, Eric Boerwinkle, , for the TOPMed Investigators

This study investigates how rare and common genetic variations contribute to QT interval duration, finding that both monogenic and polygenic factors influence QTc prolongation, with polygenic risk modulating the effect of rare variants.

Circulation · Apr 7, 2022Peer-reviewedGenetic & Genomic Medicine