Loss of developmentally derived Irf8+ macrophages promotes hyperinnervation and arrhythmia in the adult zebrafish heart
Shannon E. Paquette, Cliff I. Oduor, Amy Gaulke, Sabina Ştefan, Peter Bronk, Vanny Dafonseca, Nikolai V. Barulin, Cadence F. Lee, Rachel Carley, Alan Morrison, Bum‐Rak Choi, Jeffrey A. Bailey, Jessica S. Plavicki
This study shows that loss of Irf8+ macrophages in zebrafish leads to cardiac arrhythmia, dysfunction, and hyperinnervation.
bioRxiv · Apr 17, 2024 · PreprintSystems Biology