A Novel Susceptibility Locus in NFASC Highlights Oligodendrocytes and Myelination in Progressive Supranuclear Palsy Pathology
Pablo García‐González, Héctor Rodrigo Lara, Yaroslau Compta, Manuel Fernandez, Sven J. van der Lee, Itziar de Rojas, Laura Saiz-Aúz, Cèlia Painous, Ana Camara, Esteban Muñoz, Marı́a José Martı́, Francesc Valldeoriola, Raquel Puerta, Ignacio Illán‐Gala, Javier Pagonabarraga, , Agustı́n Ruiz
The paper performs a GWAS on PSP in the Iberian population, replicates known risk variants, and identifies a novel locus in NFASC/CNTN2 associated with oligodendrocyte and myelination processes.
medRxiv · Jun 21, 2024 · PreprintGenetic & Genomic Medicine