Elevated p21 (CDKN1a) mediates β-thalassemia erythroid apoptosis but its loss does not improve β-thalassemic erythropoiesis
Vijay Menon, Lin Miao, Raymond Hin-Suen Liang, Tasleem Arif, Anagha Menon, Laura Breda, Stefano Rivella, Saghi Ghaffari
This paper investigates the role of p21 in β-thalassemia erythroid apoptosis and shows that while reducing p21 or Foxo3 decreases apoptosis, it does not improve ineffective erythropoiesis.
bioRxiv · Mar 3, 2022 · PreprintDevelopmental Biology