P2Y6 signaling selectively regulates TLR3-induced chemokine release in murine bone marrow-derived macrophages, with opposing effects on CCL2 and CXCL1
Fatemeh Salarpour, Anais Brafine, Ashley Charre, Julie Pelletier, Jean Sévigny
This study shows that P2Y6 signaling modulates TLR3-induced chemokine release in BMDMs, reducing CCL2 and increasing CXCL1.
bioRxiv · Sep 16, 2026 · PreprintImmunology