Positively Selected Enhancer Elements Endow Tumor Cells with MetastaticCompetence
James J. Morrow, Ian Bayles, Alister PW Funnell, Tyler E. Miller, Alina Saiakhova, Michael M. Lizardo, Cynthia F. Bartels, Maaike Y. Kapteijn, Stevephen Hung, Arnulfo Mendoza, Daniel R. Chee, Jay T. Myers, Frederick Allen, Marco Gambarotti, Alberto Righi, , Peter C. Scacheri
The paper identifies metastasis-associated enhancer elements in osteosarcoma and shows they drive metastatic gene expression and can be targeted to inhibit metastasis.
bioRxiv · Jun 25, 2017 · PreprintCancer Biology