Peter C. Scacheri

Heterogeneous epigenetic variation converges on splicing dysregulation in opioid addiction

This study identifies epigenetic variation linked to opioid overdose using H3K27ac profiling and machine learning, revealing splicing dysregulation and CELF5 as a key factor.

CDK12/13 inhibition disrupts nucleolar morphology and promotes aberrant expression of IGS transcripts

This study shows CDK12/13 inhibition disrupts nucleolar structure and causes aberrant IGS rRNA transcript expression due to impaired processing and degradation.

Oncogenic reactivation of young L1s is a hallmark of colon cancer

The paper identifies oncogenic reactivation of young L1 transposable elements in colon cancer, showing PLZF loss drives this activity independently of cell division.

Cellular Maturation of Oligodendrocytes is Governed by Transient Gene Melting

This study identifies a transcriptional mechanism that controls oligodendrocyte maturation through SOX6-mediated gene melting, showing that suppressing SOX6 accelerates maturation and that an immature SOX6 signature is enriched in multiple sclerosis patient brains.

Convergence of case-specific epigenetic alterations identify a confluence of genetic vulnerabilities tied to opioid dependence

The paper identifies case-specific epigenetic alterations in opioid dependence using ChIP-seq and Hi-C, revealing convergent regulatory loci associated with genetic and environmental risk factors.

Robust Hi-C chromatin loop maps in human neurogenesis and brain tissues at high-resolution

The paper develops an improved Hi-C protocol and bias-correction pipeline to map chromatin loops in human neurogenesis and brain tissues, showing their role in neural differentiation and GWAS gene identification.

Positively Selected Enhancer Elements Endow Tumor Cells with MetastaticCompetence

The paper identifies metastasis-associated enhancer elements in osteosarcoma and shows they drive metastatic gene expression and can be targeted to inhibit metastasis.