Reduced Prefrontal PRDM2 Promotes Stress-Induced Alcohol Reinstatement Across Sexes through a dmPFC-Nucleus Accumbens Pathway
Kanat Chanthongdee, Nicola Murgia, Li Xin Xu, Tetiana Kardash, Sanne Toivainen Eloff, Andrea Coppola, Sofia Vellere, Esi Domi, Estelle Barbier
This study shows reduced PRDM2 in the prefrontal cortex increases stress-induced alcohol seeking in both sexes via a dmPFC-NAc pathway.
bioRxiv · Jun 4, 2026 · PreprintNeuroscience