Activin/TGF-beta signaling levels coordinate whole-body regeneration with genotoxic stress in Schmidtea mediterranea
Haleigh Brownlee, Amit Dubey, Nirurita Mahadev, Zachary A. Castles, Andrea Rauschmayer, Hannah M. Ashraf, Blair W. Benham-Pyle
The paper shows that activin/TGF-beta signaling inhibits regeneration after radiation in planarians, but its depletion restores regeneration by increasing stem cell proliferation despite DNA damage.
bioRxiv · Dec 29, 2025 · PreprintDevelopmental Biology