A model of Rtc-regulated RNA repair reveals heterogeneous responses to ribosome-targeting antibiotics and suggests molecular targets to potentiate their effects
Hollie J. Hindley, Zechuan Gong, Shafagh Moradian, Maria Grazia Giuliano, Andrei Sapelkin, Ioly Kotta-Loizou, Martin Buck, Christoph Engl, Andrea Y. Weiße
The paper develops a computational model of Rtc-regulated RNA repair in E. coli, revealing cell-to-cell heterogeneity in antibiotic resistance and suggesting targets to enhance antibiotic efficacy.
bioRxiv · May 20, 2024 · PreprintSystems Biology