Author

Christoph Engl

Queen Mary University of LondonORCID 0000-0003-0335-267XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Approach:statistical model· 1

Frequent Co-Authors

Shafagh MoradianiD· 2 shared Andre Sanches RibeiroiD· 1 shared Andrea Y. Weiße· 1 shared Andrei Sapelkin· 1 shared Hollie J. HindleyiD· 1 shared Ioly Kotta-Loizou· 1 shared Maria Grazia Giuliano· 1 shared Martin BuckiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

Shafagh MoradianORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintOct 6, 2025

Single-cell Analysis of Attenuation-Driven Transcription Reveals New Principles of Bacterial Gene Regulation

Shafagh Moradian, N Ali, Rahul Jagadeesan…·Christoph Engl

The paper shows that transcription attenuation modulates both burst size and frequency from a σ70 promoter, challenging previous views on frequency modulation and revealing cross-feeding as a strategy for controlling gene expression variation.

DOI 10.1101/2025.10.06.680652

bacteria (other)experimental assay

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Systems BiologybioRxivPreprintMay 20, 2024

A model of Rtc-regulated RNA repair reveals heterogeneous responses to ribosome-targeting antibiotics and suggests molecular targets to potentiate their effects

Hollie J. Hindley, Zechuan Gong, Shafagh Moradian…·Andrea Y. Weiße

The paper develops a computational model of Rtc-regulated RNA repair in E. coli, revealing cell-to-cell heterogeneity in antibiotic resistance and suggesting targets to enhance antibiotic efficacy.

DOI 10.1101/2024.05.20.594959

E. colistatistical model

𝕏 PostBluesky