Clonal heterogeneity influences the fate of new adaptive mutations
Ignacio Vázquez-Garćıa, Francisco Salinas, Jing Li, Andrej Fischer, Benjamin P. Barré, Johan Hallin, Anders Bergström, Elisa Alonso‐Perez, Jonas Warringer, Ville Mustonen, Gianni Liti
The paper investigates how clonal heterogeneity and genetic variation influence antimicrobial resistance in yeast, showing that both pre-existing and de novo mutations contribute to fitness and adaptation.
Cell Reports · Oct 1, 2017Peer-reviewedGenetics