yeast

Sequential pathways preserve kinetochore integrity in meiosis

This study identifies three distinct pathways maintaining kinetochore integrity during meiosis in budding yeast, with distinct temporal requirements and interactions involving Ctf19cCCAN, Mif2CENP-C, and Cse4CENP-A-Okp1CENP-Q-Ame1CENP-U.

Massive inter-animal horizontal gene transfer contributes to stress tolerance in the fungus gnat Bradysia coprophila

This study identifies extensive horizontal gene transfer in the fungus gnat Bradysia coprophila, showing these genes contribute to stress tolerance and ecological adaptation.

Proteome-wide profiling reveals compartment-specific RNA buffering of protein aggregation during stress

The paper uses R-DeeP to show stress-induced compartment-specific RNA buffering of protein aggregation in yeast, with nuclear RNA retention protecting nuclear proteins from aggregation.

Widespread Saccharomyces hybridization in agave fermentations arises repeatedly from asymmetric parental diversity

The paper identifies widespread Saccharomyces hybridization in agave fermentations, showing multiple independent origins and asymmetric parental genetic diversity.

Diversification of budding yeast polarization dynamics after compensatory experimental evolution

This study shows that evolution can restore cellular function without conserving microscopic organization, leading to novel molecular phenotypes in budding yeast.

Inferring modularity in genotype-phenotype maps using patterns of epistasis and pleiotropy

This paper introduces two methods, SLED and GTD, to infer modular structure in genotype-phenotype maps by combining epistasis and pleiotropy, showing they yield similar modular architectures in yeast data.

Computational Analysis of Antioxidant Effects on Stress Response Mechanisms in Candida albicans

The paper uses computational methods to analyze antioxidant effects on stress response mechanisms in Candida albicans, identifying naringenin and quercetin as potential modulators of Sir2/SIRT3 pathways.

Non-homologous end-joining is implicated in rapid and efficient caspofungin adaptation in Nakaseomyces glabratus

This study shows that non-homologous end joining (NHEJ) facilitates rapid adaptation to caspofungin in Nakaseomyces glabratus by enabling FKS2 mutations, while NHEJ-deficient strains adapt less efficiently through alternative pathways.

GOParsimony: parsimonious saltation across the Gene Ontology digraph for efficient functional annotation

GOParsimony filters GO terms to identify the most parsimonious functional annotations for gene/protein sets, outperforming existing methods in yeast and human data.

Developing synthetic auxin-based trans-kingdom signaling

This paper develops a tunable auxin-based trans-kingdom signaling system that enables cross-species communication by engineering auxin biosynthesis and response mechanisms in different organisms.

Metabolic engineering of Saccharomyces cerevisiae for improved polyphosphate production

This study engineers Saccharomyces cerevisiae to produce polyphosphate more efficiently by modifying metabolic pathways and growth conditions.

Making sense of chaos: replication and segregation defects in the yeast mcm4Chaos3 mutant

The paper investigates the mcm4Chaos3 mutation in yeast, showing it causes genome instability by impairing specific centromere-proximal origins.

Structural Determinants of Ligand-Mediated Hmg2 Mallostery

This study identifies structural features of Hmg2 that mediate GGPP-dependent misfolding and regulation, revealing that GGPP binding occurs in the transmembrane domain and loops in the lumenal domain transmit the response.

Molecular insights into the regulation of coenzyme selection in NADP-specific glutamate dehydrogenase from Saccharomyces cerevisiae

This study investigates coenzyme specificity in yeast GDH3, showing how mutations alter coenzyme preference and revealing structural and evolutionary mechanisms of coenzyme regulation.

Biosensor-guided genome-wide CRISPR screens enable cis,cis-muconic acid overproduction in yeast

This study uses biosensor-guided CRISPR screens in yeast to identify genetic targets that enhance production of cis,cis-muconic acid and protocatechuic acid.

Lac1-dependent ceramide synthesis couples septum assembly to cell separation in Schizosaccharomyces pombe

This study shows that Lac1-dependent ceramide synthesis is essential for proper septum assembly and cell separation in fission yeast.

Machine learning guided design of strong transcriptional activation domains

The paper designs functional transcriptional activation domains using machine learning and experimental validation, finding that over 90% of predicted sequences work in yeast.

Characterisation of Saccharomyces cerevisiae and Saccharomyces jurei hybrids for oenological applications

The paper identifies Saccharomyces cerevisiae and Saccharomyces jurei hybrids with improved oenological traits for wine fermentation.

Multiple domains of Mata1 transcription factor contribute to binding site specificity

The paper identifies that multiple regions of the Mat1 transcription factor contribute to DNA-binding specificity across species.

Recognition of the centromere-binding protein Ndc10 by Scm3HJURP directs Cse4CENP-A deposition at native centromeres

The paper shows Scm3HJURP facilitates Cse4CENP-A deposition at native centromeres by interacting with Ndc10, enhancing Cse4 assembly efficiency in yeast.

tWhEEL: a transcript-aware workflow for quantifying CRISPR knockout feasibility using transcriptome assembly

tWhEEL quantifies CRISPR knockout feasibility by integrating transcriptome data with guide RNA design and functional annotations to prioritize tractable biological functions and organisms.

Ktd1 is a phospho-regulated member of the Dup240 family that mediates defence against killer toxin K28

This study identifies Ktd1 as a phospho-regulated member of the Dup240 family essential for defense against the K28 killer toxin in yeast.

Joint QTL mapping reveals patterns of pleiotropy across structured environments in budding yeast

The paper uses joint QTL mapping to analyze pleiotropy patterns across structured environments in budding yeast, revealing genetic interactions influenced by environmental relationships.

Fss1, a CTNS/PQ domain protein, has dual roles in promoting fertility in Schizosaccharomyces pombe

Fission yeast Fss1, a PQ-loop membrane protein, acts in diploids to build full-thickness, chitin-containing spore walls and within spores to maintain vacuole morphology and timely germination.

Feedback control via H3K9 methylation and siRNA biogenesis autonomously maintains RNAi heterochromatin through continuous low-level transcription

The multidrug transporter Pdr5 from Saccharomyces cerevisiae is an ergosterol-modulated efflux pump

This study reports the cryo-EM structure of Pdr5, showing ergosterol binding and its effect on transporter activity, with implications for fungal drug resistance.

Whole genome duplication uncouples cell volume scaling from mitochondrial homeostasis

This study shows that polyploidy leads to reduced mitochondrial scaling and impaired metabolic function, with conserved effects across yeast and human cells.

Sugar-induced cell death in exponentially growing yeast depends on the functionality of the nonoxidative branch of the pentose phosphate pathway.

Graph-based pangenome analysis uncovers structural and functional impacts of allopolyploidization events

The paper analyzes allopolyploidization events in Brettanomyces bruxellensis using graph pangenomes to identify structural variants and their functional impacts.

Ume6 Coordinates Lysosomal Remodeling and Autophagy Through Transcriptional Repression in S. cerevisiae

This study identifies Ume6 as a transcriptional repressor that regulates vacuolar protein composition and autophagy in yeast by interacting with Rph1 and being modulated by protein kinases.