Author

Andrew A Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:eQTL / molecular QTL mapping· 2 Research Focus:differential expression· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Emmanouil T Dermitzakis· 2 shared Tuuli LappalaineniD· 2 shared Alexandra C Nica· 1 shared Alfonso BuiliD· 1 shared Ana ViñuelaiD· 1 shared Brent J Richards· 1 shared Daniel Glass· 1 shared GTEx Consortium· 1 shared

Activity by Year

2014-2017 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersGenetics

Emmanouil T Dermitzakis

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3 papers

Recent·Most cited

Estimating the causal tissues for complex traits and diseases

Halit Ongen, Andrew A Brown, Olivier Delaneau, Nikolaos Panousis, Alexandra C Nica, GTEx Consortium, Emmanouil T Dermitzakis

This paper estimates the causal tissues for complex traits and diseases by analyzing eQTLs from the GTEx consortium and adapting the RTC score to calculate tissue sharing probabilities.

Nature Genetics · Oct 23, 2017Peer-reviewedGenetics

Quantifying the regulatory effect size of cis-acting genetic variation using allelic fold change

Pejman Mohammadi, Stephane E Castel, Andrew A Brown, Tuuli Lappalainen

This paper introduces log allelic fold change (aFC) as a measure for quantifying cis-eQTL effect sizes, showing its consistency across datasets and independence from expression level and allele frequency.

Genome Research · Oct 11, 2017Peer-reviewedBioinformatics

Transcriptome Sequencing Reveals Widespread Gene-Gene and Gene-Environment Interactions

Alfonso Buil, Andrew A Brown, Tuuli Lappalainen, Ana Viñuela, Matthew N Davies, Houfeng F Zheng, Brent J Richards, Daniel Glass, Kerrin S Small, Richard Durbin, Timothy D Spector, Emmanouil T Dermitzakis

The paper uses RNA-seq and twin data to quantify gene-gene and gene-environment interactions affecting allelic specific expression.

bioRxiv · Oct 27, 2014Genomics