An alternatively spliced TREM2 isoform lacking the ligand binding domain is expressed in human brain
Benjamin C. Shaw, Henry C. Snider, Andrew K. Turner, Diana J. Zajac, James F. Simpson, Steven Estus
The paper identifies a novel alternatively spliced TREM2 isoform lacking the ligand binding domain, which is expressed in both AD and non-AD brain and may function as an inhibitor of TREM2.
Journal of Alzheimer s Disease · May 3, 2022Peer-reviewedMolecular Biology