Author

Diana J. Zajac

University of KentuckyORCID 0000-0002-9488-5190Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Steven EstusiD· 2 shared Adeline E. WalshiD· 1 shared Amy A. Gorman· 1 shared Andrew K. Turner· 1 shared Benjamin C. ShawiD· 1 shared Danielle S. Goulding· 1 shared Douglas A. HarrisoniD· 1 shared Henry C. SnideriD· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Steven EstusORCID

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2 papers

Recent·Most cited

ApoE4 drives maladaptive heterogeneity and immunometabolic responses of astrocytes

Sangderk Lee, Holden C. Williams, Amy A. Gorman, Nicholas A. Devanney, Douglas A. Harrison, Adeline E. Walsh, Danielle S. Goulding, Tony Tuck, James L. Schwartz, Diana J. Zajac, Shannon L. Macauley, Steven Estus, Julia TCW, Lance A. Johnson, Josh M. Morganti

This study shows that ApoE4 alters astrocyte immunometabolic responses to inflammation by changing their transcriptional profiles and relying on cRel transcription factor activity.

bioRxiv · Feb 6, 2023 · PreprintNeuroscience

An alternatively spliced TREM2 isoform lacking the ligand binding domain is expressed in human brain

Benjamin C. Shaw, Henry C. Snider, Andrew K. Turner, Diana J. Zajac, James F. Simpson, Steven Estus

The paper identifies a novel alternatively spliced TREM2 isoform lacking the ligand binding domain, which is expressed in both AD and non-AD brain and may function as an inhibitor of TREM2.

Journal of Alzheimer s Disease · May 3, 2022Peer-reviewedMolecular Biology