Characterization of Electrophysiological and Transcriptomic Alterations in Patient-Derived Neurons from CHAMP1 Syndrome
Dailey Nettles, Christina Stanton, Zach Hunter, Bryan Granger, Elizabeth Wallace, Andrew Lutsky, Suganya Subramanian, Meris Privette, Lori McMahon, Stefano Berto
This study investigates CHAMP1 mutations' effects on neuronal development using patient-derived neurons, revealing disruptions in DNA repair, membrane excitability, and synaptic connectivity.
bioRxiv · Jul 29, 2026 · PreprintNeuroscience