Fragile X Mental Retardation Protein regulates R-loop formation and prevents global chromosome fragility
Arijita Chakraborty, Piroon Jenjaroenpun, Jing Li, Sami El-Hilali, Andrew McCulley, Brian K. Haarer, Elizabeth A. Hoffman, Aimee Belak, Audrey Thorland, Heidi Hehnly, Carl L. Schildkraut, Chun-Long Chen, Vladimir A. Kuznetsov, Wenyi Feng
This study shows FMRP prevents chromosome fragility by reducing R-loop formation and identifies novel FXS-susceptible genes.
Cell Reports · Sep 1, 2020Peer-reviewedGenomics