Author

Carl L. Schildkraut

Albert Einstein College of Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 3 Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Settapong T Kosiyatrakul· 3 shared Binghui SheniD· 2 shared Dong ZhangiD· 2 shared Zheng LiiD· 2 shared Aimee Belak· 1 shared Aman SharmaiD· 1 shared Andrew McCulley· 1 shared Anthony FernandeziD· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersMolecular Biology

Settapong T Kosiyatrakul

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Author profile →

5 papers

Recent·Most cited

DNA2 and FANCM function in two distinctive pathways in disrupting TERRA R-loops and suppressing replication stress at ALT telomeres

Ashwin Ragupathi, Heba Zuhair Abid, Yun Chen, Rongwei Zhao, Settapong T Kosiyatrakul, Derin I. Yetil, Julia Neiswander, Rachel Feltman, Shannon Thomas, Benjamin Yusupov, Manrose Singh, Zheng Li, Binghui Shen, Huaiying Zhang, Hsueh-Ping C. Chu, , Dong Zhang

This study shows DNA2 and FANCM function in distinct pathways to suppress replication stress at ALT telomeres, with their combined depletion causing synthetic lethality in ALT+ cancers.

bioRxiv · May 22, 2025 · PreprintCancer Biology

DNA2 and MSH2 activity collectively mediate chemically stabilized G4 for efficient telomere replication

Anthony Fernandez, Tingting Zhou, Robert Steven Esworthy, Changxian Shen, Helen Liu, Jessica D. Hess, Hang Yuan, Nian Liu, Guojun Shi, Mian Zhou, Settapong T Kosiyatrakul, Vikas Gaur, Joshua A. Sommers, Winfried Edelmann, Guo‐Min Li, , Binghui Shen

The paper shows DNA2 and MSH2 work together to remove G4 structures at telomeres, preventing replication issues and telomere instability.

bioRxiv · Apr 4, 2025 · PreprintMolecular Biology

A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells

Sana Ahmed‐Seghir, Manisha Jalan, Helen E. Grimsley, Aman Sharma, Shyam Twayana, Settapong T Kosiyatrakul, Christopher M. Thompson, Carl L. Schildkraut, Simon N. Powell

The paper shows that a single replication fork barrier activates a local ATR-dependent checkpoint response in human cells, leading to localized DNA damage signaling without affecting global replication.

bioRxiv · Mar 26, 2023 · PreprintMolecular Biology

Fragile X Mental Retardation Protein regulates R-loop formation and prevents global chromosome fragility

Arijita Chakraborty, Piroon Jenjaroenpun, Jing Li, Sami El-Hilali, Andrew McCulley, Brian K. Haarer, Elizabeth A. Hoffman, Aimee Belak, Audrey Thorland, Heidi Hehnly, Carl L. Schildkraut, Chun-Long Chen, Vladimir A. Kuznetsov, Wenyi Feng

This study shows FMRP prevents chromosome fragility by reducing R-loop formation and identifies novel FXS-susceptible genes.

Cell Reports · Sep 1, 2020Peer-reviewedGenomics

Chromosomal rearrangements at hypomethylated Satellite 2 sequences are associated with impaired replication efficiency and increased fork stalling

Yannick Delpu, Thomas McNamara, Patrick T. Griffin, Suhail Kaleem, Shubhada Narayan, Carl L. Schildkraut, Karen H. Miga, Mamta Tahiliani

The paper shows hypomethylation of Satellite 2 sequences impairs DNA replication, leading to chromosomal rearrangements and genomic instability.

bioRxiv · Feb 19, 2019 · PreprintMolecular Biology