Structural Integrity of RyR2 Clusters Controls Cardiac Calcium Leak
Andrew Noren, Yohannes Shiferaw
The paper develops a computational model of RyR2 clusters to show that structural integrity exponentially affects Ca spark frequency, highlighting it as a therapeutic target for cardiac arrhythmias.
Frontiers in Physiology · Dec 9, 2025Peer-reviewedBiophysics