Yohannes Shiferaw

Calsequestrin localization at RyR2 clusters enables calcium wave propagation in ventricular myocytes

The paper develops a 3D computational model of mouse ventricular myocytes to show that calsequestrin2 (CASQ2) co-localization with RyR2 clusters is essential for reliable calcium wave propagation.

Structural Integrity of RyR2 Clusters Controls Cardiac Calcium Leak

The paper develops a computational model of RyR2 clusters to show that structural integrity exponentially affects Ca spark frequency, highlighting it as a therapeutic target for cardiac arrhythmias.

Mechanism of Arrhythmogenesis Driven by Early After Depolarizations in Cardiac Tissue

This study develops a computational model of early after depolarizations (EADs) in cardiac tissue, showing that EADs can emerge through a discontinuous bifurcation leading to arrhythmogenic alternans without ectopic beats.

Two-variable nullcline analysis of ionic general equilibrium predicts calcium homeostasis in ventricular myocytes

The paper uses a two-variable nullcline analysis to predict calcium homeostasis in ventricular myocytes and explains why SERCA gene therapy may fail to improve contraction despite increasing SERCA expression.