Chronic hypertension disrupts the blood-brain barrier in the ventral hippocampus in females but not males in a rat model of vascular cognitive impairment
Jared Luchetta, Gianna M DeMarco, Anduela Thaqi, Gabrielle A Bernstein, Swapna E Chavara, Emily D Schellinger, Dinlin Chen, Abbie C Chapman
This study shows chronic hypertension increases BBB permeability and anxiety-like behaviors in female rats but not males in a vascular cognitive impairment model.
bioRxiv · Nov 3, 2026 · PreprintNeuroscience