Chemical genetic screen for substrates of autism risk gene NUAK1 uncovers its role in ARF6 mediated dendritic spine maturation
Josilyn R. Sejd, Swagatika Paul, Daphnée M. Marciniak, Moira Cornell, Angel Sondhi, Shao‐En Ong, Smita Yadav
This study identifies NUAK1 substrates in neurons and shows that NUAK1 phosphorylation of PSD3 regulates ARF6 activation and dendritic spine maturation, linking NUAK1 to autism risk.
bioRxiv · Sep 22, 2026 · PreprintNeuroscience